An emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room.

Based on the Pretty Little Liars series of young adult novels by Sara Shepard, the series follows the lives of four girls — Spencer, Hanna, Aria, and Emily — whose clique falls apart after the disappearance of their queen bee, Alison. One year later, they begin receiving messages from someone using the name "A" who threatens to expose their secrets — including long-hidden ones they thought only Alison knew.