There's a new Ghostface in town terrorizing teens, 25 years after Woodsboro's first killing spree — and old friends must reunite to stop the slaughter.

When a strange chemical mutates three animals into overgrown, aggressive beasts, a primatologist must find an antidote before they destroy the city.

Sidney Prescott, now the author of a self-help book, returns home to Woodsboro on the last stop of her book tour. There she reconnects with Sheriff Dewey and Gale, who are now married, as well as her cousin Jill and her Aunt Kate. Unfortunately, Sidney's appearance also brings about the return of Ghostface, putting Sidney, Gale, and Dewey, along with Jill, her friends, and the whole town of Woodsboro in danger.

A favor for a woman from her past throws the life of a pregnant, retired porn star into chaos.