William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

As young and recently single parents, Clara and Alex have two completely different styles of parenting. While helicopter mom Clara hovers over her son Oliver, Alex's daughter Emma feels out of touch with her father's life. Their two worlds collide when Alex proposes that his marketing company shoot a commercial at the kids' school and Clara, up for election as the parent group president, objects the idea. The commercial is Alex's last hope for keeping the company afloat, so in a moment of desperation, he nominates himself for parent group president. In a surprising turn of events, Clara and Alex tie for president and must work together to run the group until the mandated re-vote. The bitter rivals struggle for power, outfoxing each other any chance they get, until the matter of raising their children puts things into perspective. Clara and Alex come to a mutual understanding and even ignite a spark of romance.