After a disease kills 98% of America's children, the surviving 2% develop superpowers and are placed in internment camps. A 16-year-old girl escapes her camp and joins a group of other teens on the run from the government.

While Po and his father are visiting a secret panda village, an evil spirit threatens all of China, forcing Po to form a ragtag army to fight back.

With his fists up and belly full, Po embarks on a perilous journey with the Furious Five to take on a frightful new enemy and save the art of kung fu.